Kim Merriam asks about HOPE fixation,
and Joyce Weems and Bryan Hewlett reply:
Depending on the Pathologist doing the grossing, I think it's where you hope 
fixation will occur.

Hey, I resemble that remark!

Seriously, this technique is from Germany and seems to be a research 
technique - at least, I can't think of a clinical use for it. Note that it's not 
actually a fixative. See
www.hope-fixation.com
HEPES is one of the Good buffers (see Good's article in the JBC, 1966) - look 
it up in a Sigma catalog for more information.

Bob Richmond
Samurai Pathologist
Knoxville TN
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