Re: Her 2 and fixation
This has been a problem for us as well. The FDA approval for Her2Neu has only been granted for 10% NBF. We are a Prefer fixative lab so we have to send our Her2s out for FISH.
Mary Bryhan HT (ASCP)
Team Leader Anatomic Pathology
Northern Michigan Hospital
Petoskey, MI USA
>>> "Marshall Terry Dr, Consultant Histopathologist" 01/27/03 08:41AM >>>
We have just noticed from Dako that:
"Her 2 positivity is "compromised by other than phosphate buffered formalin fixation" "
Since Her 2 seems to be the latest craze, this is of some concern.
Has anyone got any further details, or a rebuttal of this, particularly in relation to zinc fixation?
Terry L Marshall B.A.(Law), M.B.Ch.B., F.R.C.Path
Rotherham General Hospital, Yorkshire
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