This has been a problem for us as well.  The FDA approval for Her2Neu has only been granted for 10% NBF.  We are a Prefer fixative lab so we have to send our Her2s out for FISH.  

Mary Bryhan HT (ASCP)
Team Leader Anatomic Pathology
Northern Michigan Hospital
Petoskey, MI USA

>>> "Marshall Terry Dr, Consultant Histopathologist"  01/27/03 08:41AM >>>
We have just noticed from Dako that:

"Her 2 positivity is "compromised by other than phosphate buffered formalin fixation" "

Since Her 2 seems to be the latest craze, this is of some concern.
Has anyone got any further details, or a rebuttal of this, particularly in relation to zinc fixation?



Terry L Marshall B.A.(Law), M.B.Ch.B., F.R.C.Path
Consultant Histopathologist
Rotherham General Hospital, Yorkshire
terry.marshall@rothgen.nhs.uk