RE: Nuclear PSA staining

From:"Nader, Alexander"

> For those of you doing immunohistochemical staining for
> prostate-specific antigen (PSA), have you ever seen nuclear staining
> along with cytoplasmic reactivity in prostatic adenocarcinoma?  No, we
> do not use heat pretreatment.  Thanks.

Yes, I remember having seen that phenomenon one or two times in high grade
(Gleason >8) carcinomas. Sometimes I mention staining of the nucleoli only,
like in CD20/L26. 

Any idea why nucleoli sometimes react with quite a lot of antibodies?

Alexander Nader

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