RE: Her 2 and fixation
And we were told by our reference lab that Prefer is unsuitable for FISH. We
changed everything to 10% NBF. Also, patients are not allowed in some
clinical trials if FDA approved methods have not been used for performing
the EF, PR, Her2.
Saint Joseph's Hospital of Atlanta
404-851-7831 - fax
From: Mary Bryhan [mailto:mbryhan@NORTHERNHEALTH.ORG]
Sent: Monday, January 27, 2003 10:26 AM
To: firstname.lastname@example.org; Terry.Marshall@rothgen.nhs.uk
Subject: Re: Her 2 and fixation
This has been a problem for us as well. The FDA approval for Her2Neu has
only been granted for 10% NBF. We are a Prefer fixative lab so we have to
send our Her2s out for FISH.
Mary Bryhan HT (ASCP)
Team Leader Anatomic Pathology
Northern Michigan Hospital
Petoskey, MI USA
>>> "Marshall Terry Dr, Consultant Histopathologist"
01/27/03 08:41AM >>>
We have just noticed from Dako that:
"Her 2 positivity is "compromised by other than phosphate buffered formalin
Since Her 2 seems to be the latest craze, this is of some concern.
Has anyone got any further details, or a rebuttal of this, particularly in
relation to zinc fixation?
Terry L Marshall B.A.(Law), M.B.Ch.B., F.R.C.Path
Rotherham General Hospital, Yorkshire
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