Re: PAS/norcadia

Have you considered Zygomycosis (Mucor or Rhysopus) ? The hyphae of 
Zygomycosis are regularly septate, 4-10 Ám in diameter with an eosinophilic 
sheath (Splendore-Hoeppli phenomenon) 2-6 Ám in diameter. They have 
fingerlike arrangements similar to that found in sporotrichosis, 
coccidioidomycosis, blastomycosis and paracoccidioidomycosis. Inflammatory 
reactions are granulomatous with infiltrates seen containing foreign body 
giant cells and phagocytized hyphae. Acute reactions consist of eosinophils,=20
lymphocytes, and plasma cells. Eosinophils may result in an eosinophilic 
abscess in some focal areas and the mycelium are Grocott and PAS positive.

Eric C. Kellar
University of Pittsburgh Medical Center


Dear histoneters, we are having trouble distinguishing Norcadia and
Actinomyces on a paraffin section. The texts I've consulted don't list
norcadia giving a pas positive reaction. The organism we have has pas
positive mycelium within a sulpur-granulated pustule. 

Thanks in advance 

Gerard Spoelstra
School of Biomedical Science
Murdoch University
Western Australia

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