Re: PAS/norcadia
Have you considered Zygomycosis (Mucor or Rhysopus) ? The hyphae of
Zygomycosis are regularly septate, 4-10 µm in diameter with an eosinophilic
sheath (Splendore-Hoeppli phenomenon) 2-6 µm in diameter. They have
fingerlike arrangements similar to that found in sporotrichosis,
coccidioidomycosis, blastomycosis and paracoccidioidomycosis. Inflammatory
reactions are granulomatous with infiltrates seen containing foreign body
giant cells and phagocytized hyphae. Acute reactions consist of eosinophils,=20
lymphocytes, and plasma cells. Eosinophils may result in an eosinophilic
abscess in some focal areas and the mycelium are Grocott and PAS positive.
Eric C. Kellar
University of Pittsburgh Medical Center
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Dear histoneters, we are having trouble distinguishing Norcadia and
Actinomyces on a paraffin section. The texts I've consulted don't list
norcadia giving a pas positive reaction. The organism we have has pas
positive mycelium within a sulpur-granulated pustule.
Thanks in advance
Gerard Spoelstra
School of Biomedical Science
Murdoch University
Western Australia
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