reference for CJD - sodium hydroxide
Sodium hydroxide solution slopped around in large quantities to combat prions?
Obviously we're in a situation where satisfying the demands of bureaucrats is
more important than the safety of laboratory people - but strong solutions of
sodium hydroxide, handled in large quantities in crowded laboratories by
numerous people of varying degrees of consciousness - are a significantly
hazardous material, particularly for eye injuries. (The same arguments apply
to formic acid.)
Obviously prions are a laboratory hazard, but they're one we've lived with
for a long time, and as far as I know there is still no known case of
Creutzfeldt-Jakob disease resulting from exposure to pathology specimens. I
think it remains to be shown that we need any change in our methods. (For one
thing, we'd have to return to open-bucket tissue processing, since a modern
tissue processor cannot be cleared of prions.)
One thing I would caution against is doing an autopsy on a body with a prion
disease - this undertaking clearly requires more containment than is possible
in an ordinary autopsy facility. (Somehow bureaucrats have always managed to
make the assumption that an autopsy could not be an infection hazard.)
Bob Richmond
Samurai Pathologist
Knoxville TN
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