Fw: Formalin/Alcohol Question

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From:John Spair <jspair@multicare.com> (by way of histonet)
To:histonet <histonet@magicnet.net>
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Some people in pathology say they have experienced a loss of
immunoreactivity when tissues are fixed in formol-alcohol.  One lab for
instance that we have referred out ICC, won't do ICC on any tissue fixed in
formol-alcohol.  Another lab says they have no trouble whatsover.  Recently
our pathologists started fixing our breast and colon cases in formol-alcohol
and since most of these breast cases get a "breast battery" panel done on
them, such as ER/PR, etc. - a concern has arisen between our pathology group
about the use of formol-alcohol.

I'm curious to find out other histonetters opinions, or experiences before
making a final decision and telling our pathology group that we cannot use
it any longer.  Thank you.

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