scrapie, formic acid treatment

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From:Gayle Callis <> (by way of histonet)
To:histonet <>
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Interesting question and now for another one, what if the fixative itself
has formic acid in it?  I've seen Bouins made up with formic acid
instead of acetic acid, and it may be a way to achieve some type of
fixation  (inactivate the prion, and still have some
type of fixation for good sectioning.  Just a thought even though
Bouins is not fun to handle at times.

We have all of Hadley Marsh's old scrapie tissues stored somewhere in la la
storage, one of the scrapie experts from millenia ago, and never thought
about the possibility of prion problems, sorry for poetic sounds.
However, who's to say it ISN'T a problem, have they proven it???  I would
err to side of caution, and now hoping they do not take those old blocks
out of mothballs.

Gayle Callis

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