RE: [Histonet] Thanks! (about few questions about IHC DAB stainin g)

From:"Houston, Ronnie"

Erbitux is the monoclonal antibody therapy that has been FDA approved for
treatment of colon cancers. It specifically binds to EGFR, and effectively
blocks some kinases resulting in inhibiting cell growth, inducing apoptosis,
and decreasing MMP and VEGF production.

EGFR is expressed in many normal epithelia. It is over-expressed in many
human cancers including colon and rectal.

The clinical studies to date, and those that gained FDA approval of the
drug, have required positive expression of EGFR for enrollment. The results
were based on the use of DakoCytomation's EGFR pharmDx kit.

One concern of oncologists at present is that the clinical trails never
included any patients who had negative expression of EGFR, so they do not
know if these patients will respond to the drug also.

Dako's kit has been about for some time now.

Ronnie Houston
Director of Anatomic Pathology
Bon Secours HealthPartners Laboratories
5801 Bremo Road
Richmond, VA 23226
(804) 287 7972
(804) 287 7906 - fax 

-----Original Message-----
From: Mitchell, Jeannette M. []
Sent: Thursday, February 19, 2004 8:34 AM
Subject: RE: [Histonet] Thanks! (about few questions about IHC DAB

 Does anyone out there do the EGFR test? I know that Dakocytomation is
coming out  with it but someone here is requesting and wants it now.


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