RE: Stain information (TZANC test)
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From: | "RUSS ALLISON" <Allison@Cardiff.ac.uk> |
To: | histonet@pathology.swmed.edu |
Reply-To: | |
Content-Type: | text/plain; charset=US-ASCII |
Dear Bill (Sinai),
Terry's comments on Tzanc cells are appropriate, as you would
expect. Most commonly, Tzanc cells are considered a useful
indicator of pemphigus vulgaris in the differential diagnosis of
bullous lesions. Immunofluorescence is the indicator of choice.
However, Tzanc cells can be seen and identified in lesion smears,
but usually only if an intact bulla is broken to prepare the smear
and the base of the lesion is sampled. They are quite
characteristic and easily recognised. Suggest looking at a good
dermatology or oral pathology text-book to see pictures. Then you
will know them when you see them!
There is no "stain" for them - haematoxylin is as good as any and
better than most - change that, best of all!
Russ Allison,
Dental School
Cardiff
Wales
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