RE: [Histonet] Differentiating between carcinoid & other neuroendocrine tumours

From:"Richard Cartun"

What is the tissue source?  I would think the good old "H&E" and
clinical history (hormone levels) would be your best bet.  I have found
IHC for serotonin to be helpful in identifying midgut carcinoid tumors. 
IHC for insulin, glucagon, and somatostatin can be helpful for islet
cell tumors.

Richard Cartun

>>> "Shelkowsky, Ben"  12/04/03 12:20PM >>>
One other thing about this subject. I'm sure one of our immuno experts
on the Histonet might have some suggestions on a more definitive pathway
of staining.

	-----Original Message----- 
	From: on behalf of Fearn
	Sent: Thu 12/4/2003 6:30 AM 
	To: Histonet (E-mail) 
	Subject: [Histonet] Differentiating between carcinoid & other
neuroendocrine tumours

	We're trying to differentiate between a carcinoid tumour and
	neuroendocrine tumours. Grimelius, chromogranin & synaptophysin
are positive
	and we need to be more specific as to the type of tumour, with
very little
	tissue left in the block! I've been told staining for
argentaffin granules
	would be best, but does anyone know which method is the best to
go for?
	Thanks, in advance, for your help.
	Histonet mailing list 

Confidentiality Notice:
This is a transmission from Community Hospital of the Monterey
Peninsula.  This message and any attached documents may be confidential
and contain information protected by state and federal medical privacy
statutes.  They are intended only for the use of the addressee.  If you
are not the intended recipient, any disclosure, copying, or distribution
of this information is strictly prohibited.  If you received this
transmission in error, please accept our apologies and notify the

Thank you.

Histonet mailing list

Histonet mailing list

<< Previous Message | Next Message >>