RE: Fixation Classification
Tony, I think it would be something like "crosslinking" and
"non-crosslinking" which would take into account the actual mechanisms of,
say, formalin vs picric acid.
From: Tony Henwood [mailto:firstname.lastname@example.org]
Sent: Thursday, December 13, 2001 5:18 PM
Subject: Fixation Classification
Barry Rittman in August this year contributed to
"Fixatives used to be described as additive or non
Additive fixatives are those in which the fixing agent
attaches to the
Non additive fixatives on the other hand cause changes
in the proteins
that cause them to become changed, often used to be
e.g. formalin., picric acid are additive, ethanol is
Because of the complexity of fixation and the great
variety of agents
used, the terms additive and non additive are not now
The question I have been pondering is "What is the
preferred classification for fixatives that we should
Luna suggested the terms hard and soft fixatives,
basing his classification on nuclear appearance.
What does everyone else think?
Regards and Happy Christmas and a good new year
Tony Henwood JP BAppSc GradDipSysAnaly CT(ASC)
The Childrens Hospital at Westmead
Locked Bag 4001
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