Re: TTF(thyroid antibody)

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From:Phyllis Davie <>
To:"Josefa Nava" <>, <>
Date:Thu, 19 Aug 99 20:12:15 -0700
Content-Type:text/plain; charset="US-ASCII"

  TTF stands for Thyroid Transcription Factor.  TTF-1 is a member of a 
family of nuclear regulatory proteins that is expressed almost 
exclusively in lung and thyroid epithelium.  TTF-1 is positive in lung 
adenocarcinomas and lung neuroendocrine carcinomas, but NOT squamous cell 
carcinomas.  It is also positive in neuroendocrine carcinomas from 
non-lung sites, as well as medullary thyroid carcinomas.  However, it is 
negative in other carcinomas, and thus can be useful in identifying 
tumors of lung origin (within the appropriate clinical context, of 
course).  This antibody is available from NeoMarkers (phone 800-828-1628) 
catalog # MS-699-P, and works very well on formalin tissue with HIER.

Phyllis Davie
PhenoPath Laboratories

>Can someone tell me what TTF antibody stands for. I was told it is for
>thyroid . Please let me know what company I can order it from.
>Thank you.
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