the prions are NOT considered sensitive to the agents you've mentioned
(alcohols, clearing agents and paraffin).
 
go to the following link
http://www.cap.org/toolbox/index.htm
ans search for  CJD
you will find several sources of useful information for download.
 
 
 
Vinnie Della Speranza
Manager for Anatomic Pathology Services
Medical University of South Carolina
165 Ashley Avenue  Suite 309
Charleston, SC 29425
Ph: 843-792-6353
fax: 843-792-8974

>>> =?UNKNOWN?Q?Agust=EDn?= Venzano 
08/12/02 02:35PM >>>
Dear netters: I'm in need of some up to date literature on the
following=

Are prions definitely killed i.e. is their pathogenic potential
destroyed by
alcohols, clearing agents and hot paraffin during routine histologic
processing? Any MD or DVM knows about TSE (=BSE, FSE,
CWD, CJD, etc.)-causing agents' resistance to formalin fixation. But
who can
document the current knowledge on this topics? It is in favor of our
own
biosecurity!!

Thank you very much

Agustin Jose Venzano Halliburton
DVM, INTA, Argentina