RE: CK-7 in sarcomas

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From:"Nader, Alexander" <>
To:'Richard Cartun' <>, Histonet <>

> -----Original Message-----
> From: Richard Cartun []
> Sent: Thursday, August 10, 2000 11:16 PM
> To: Histonet
> Subject: CK-7 in sarcomas
> I have seen cytokeratin-7 (CK-7) in myofibroblasts, but has 
> anyone seen CK-7 immunoreactivity in "true" sarcomas?  

I never tried it, but I wouldn't be too impressed if CK-7 is expressed on
some angiosarcomas as these tumors very often are - at least focally-
positive for "epithelial" markers.

Take also a look at:
Smith TA, Machen SK, Fisher C, Goldblum JR. Usefulness of cytokeratin
subsets for distinguishing monophasic synovial sarcoma from malignant
peripheral nerve sheath tumor. 
Am J Clin Pathol 1999 Nov;112:641-8.

Alexander Nader

PS: Although it's a litle bit off-topic: but what's a "true" sarcoma?
Coming from developmental biology to pathology I always wondered why renal
cell tumors are called "carcinomas"!

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