Re: Mast cell control tissues

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From:Tim Morken <>
Date:Thu, 08 Apr 1999 08:14:19 -0400 (EDT)

Mast cells are found primarily in the connective tissue of the skin 
and mucous membranes. They are also found in the thymus and the 
capsules of most organs. Look around small blood vessels. There are 
none in the CNS.  The location gives a hint of their function: 
protection against foriegn elements through quick distribution of 
chemicals which help eliminate those elements.

Mast cells are part of the immune system and are reactive to 
antibodies produced by plasma cells against foriegn elements. The 
granules in mast cells contain histamine (dialates blood vessels 
allowing more blood to the affected area) and heparin (prevents blood 
clotting allowing flushing of tissue), among other things. When you 
take an anti-histamine you are using a drug that blocks receptors on 
mast cells and prevents their activation.

Those who are allergic to bees and other stinging insects have a 
super-sensitve mast cell system which all release their contents at 
once causing anaphylaxis.

Tim Morken, B.A., EMT(MSA), HTL(ASCP)  
Infectious Disease Pathology 
Centers for Disease Control 
1600 Clifton Rd. 
Atlanta, GA 30333 
FAX:  (404)639-3043 

----Original Message Follows----
Subject: Mast cell control
Date: Wed, 07 Apr 1999 18:16:49 -0400 (EDT)

We are looking for a mast cell control.  In any of the literature I 

read it 
says any tissue with mast cells in it should work..wel the problem is 

tissue.  Please do not laugh at such a question but does anyone have 

suggestions as to specific tissue that contains mast cells?  Thank you 

your help.


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