RE: hercep

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From:"Connolly, Brett" <>
To:histonet <>, "'Dr. Naseem'" <>
Date:Wed, 14 Apr 1999 15:03:52 -0400

HercepTest is the FDA approved in vitro diagnostic test marketed by DAKO
Corp. It is a semi-quantitative immunohistochemical assay to determine
overexpression of HER2 protein (human epidermal growth factor receptor) in
breast cancer tissue. The assay can be performed on FFPE specimens. The HER2
protein is a membrane receptor tyrosine kinase. The HER2 gene ( a.k.a. c-erb
B-2 or neu or HER-2/neu )  is homologous, but distinct from EGFR (HER1) and
may also show amplification in a percentage of breast cancer patients.

For more information see the DAKO website at

A good review is: Ross et al., The HER-2/neu Oncogene in Breast Cancer:
Prognostic Factor, Predictive Factor, and Target for Therapy, Stem Cells


Brett M. Connolly,  Ph.D., HTL
Merck Research Laboratories
Dept. of Human Genetics
P.O. Box 4
Sumneytown Pike & Broad St.
West Point, PA 19486
FAX. 215-652-2075

> ----------
> From: 	Dr. Naseem
> Sent: 	Wednesday, April 14, 1999 1:03 AM
> To: 	HistoNet
> Subject: 	hercep
> hello colleagues
> i want to know  what is this HERCEP TEST? 
> Dr. Naseem Ahmed

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