RE: hercep
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From: | "Connolly, Brett" <brett_connolly@merck.com> |
To: | histonet <histonet@Pathology.swmed.edu>, "'Dr. Naseem'" <nasimas@khi.compol.com> |
Reply-To: | |
Date: | Wed, 14 Apr 1999 15:03:52 -0400 |
Content-Type: | text/plain |
HercepTest is the FDA approved in vitro diagnostic test marketed by DAKO
Corp. It is a semi-quantitative immunohistochemical assay to determine
overexpression of HER2 protein (human epidermal growth factor receptor) in
breast cancer tissue. The assay can be performed on FFPE specimens. The HER2
protein is a membrane receptor tyrosine kinase. The HER2 gene ( a.k.a. c-erb
B-2 or neu or HER-2/neu ) is homologous, but distinct from EGFR (HER1) and
may also show amplification in a percentage of breast cancer patients.
For more information see the DAKO website at http://www.dakousa.com/dakousa
A good review is: Ross et al., The HER-2/neu Oncogene in Breast Cancer:
Prognostic Factor, Predictive Factor, and Target for Therapy, Stem Cells
1998;16:413-428.
Regards,
Brett
Brett M. Connolly, Ph.D., HTL
Merck Research Laboratories
Dept. of Human Genetics
WP26A-3000
P.O. Box 4
Sumneytown Pike & Broad St.
West Point, PA 19486
ph.215-652-2501
FAX. 215-652-2075
email:brett_connolly@merck.com
> ----------
> From: Dr. Naseem
> Sent: Wednesday, April 14, 1999 1:03 AM
> To: HistoNet
> Subject: hercep
>
> hello colleagues
>
> i want to know what is this HERCEP TEST?
> Dr. Naseem Ahmed
>
>
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