We have had very good results with Thermo Shandon Teflon-coated high profile blades.   I have cut a whole tray (24 blocks) frequently with one blade if there's no calcium (not to mention staples!) in the tissue.   You should NOT wipe off Teflon-coated blades, since it removes the Teflon --- we usually brush paraffin trimmings away.    
 
Karen
krat18@aol.com
 
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