Bonjour!

We tried  measuring the "blood" pressure generated by our perfusion
techniques but were unsuccessful.  Back to  calculating blood volumes,
blood circulation times (using formulas from  vetinarian school documents).
A 35 g mouse, has a blood volume of 1.75 - 2.4 ml (blood volume=
50-80ml/kg) physiological blood flow rates are 6.3 - 8.7 ml/min and
systolic blood pressure of 113 mm Hg.

Conclusions:
Our perfusion rate of 2 ml/min is therefore much lower than physiological
flow rates.

What maximum rates have been used in your experiments (without exploding
the cardiovascular system)?

Nancy Walker
Molecular Pharmacology

Sanofi-Synthelbo Research
B.P. 37 Labége Innopole
31676 LABEGE CEDEX FRANCE

nancy.walker@sanofi-synthelabo.com
tel : (33)561004179  fax :(33)561004001





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