[Histonet] eosinophilic crystals in mouse lung answer

From:Gayle Callis

Dear All, 

The question has been answered by Dr. JoAnn Schuh, and much appreciated. 

She wrote:  

Eosinophilic crystals in mouse lungs are not an artefact.  The crystals 
form from an endogenous protein, YM-1, that is an autocrystallizing 
protein.  These crystals in the lung, and a related crystal-forming 
protein (YM-2) in the gastrointestinal tract are most frequent in 
certain strains of mice (C57BL/6, 129, SW, etc.) and generally are 
associated with lung or gastrointestinal injury, respectively.  FYI, I 
have attached a publication on the characterization of these crystals in 
the lungs.

Best regards,


She also attached a pdf of publication and if anyone is interested via
private email. 

Gayle Callis
Research Histopathology Supervisor
Veterinary Molecular Biology 
Montana State University - Bozeman
PO Box 173610
Bozeman MT 59717-3610
406 994-6367 (lab with voice mail)
406 994-4303 (FAX)

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