Re: Oligodendrocyte marker

From:Joseph Lee

I don't use anti-CNP. But, according to some refs,
anti-CNP monoclonal antibodies has allowed CNP to be
exploited as a specific immunological marker for
oligodendrocytes and Schwann cellsntwo cell types that
elaborate and maintain myelin sheaths in the central
nervous system (CNS) and peripheral nervous system
(PNS), respectively.

J Neurochem 1983 Dec;41(6):1664-71
Sprinkle TJ, Sheedlo HJ, Buxton TB, Rissing JP.
Immunochemical identification of 2', 3'-cyclic
nucleotide 3'-phosphodiesterase in central and
peripheral nervous system myelin, the Wolfgram protein
fraction, and bovine oligodendrocytes.


--- "Polkovitch, Debbie   [PRDUS]"
> Hello,
> Does anyone know of a specific marker to identify
> Oligodendrocytes?  We have
> performed IHC using several antibodies from several
> companies and have not
> had very good luck?  Does anyone have a favorite
> antibody?  Are there any
> other methods (i.e. special stains) that can be used
> to detect
> Oligodendrocytes or are there any specific kits on
> the market?
> Thanks,  
> Deborah Polkovitch, B.S. MT(ASCP)QIHC
> Drug Discovery, MorphoMetrics Team, DSE-435
> J&J Pharmaceutical Research and Development 
> Welsh and McKean Rds., P.O. Box 776
> Spring House, PA 19477-0776
> (215) 628-5392

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