MART 1 variability

From:Jeffrey Silverman

Hi Vinnie,
In my experience and in the literature, MART 1 immunoreactivity can vary from melanoma to melanoma and within different areas of a given melanoma.
Am J Dermatopathol 2000 Jun;22(3):247-50

 The same phenomenon occurs with HMB-45. If your control nevus was good, there is no reason to doubt the results. In one study, only 10 of 22 (45%) of malignant melanomas showed MART 1 staining in more than half of the tumor cells. J Am Acad Dermatol 2000 Mar;42(3):496-500
Also spindle cell or desmoplastic melanomas are usually MART 1 negative or only focally positive Am J Surg Pathol 1998 Aug;22(8):976-82
Hope this helps
Jeff Silverman
Southside Hospital
Bay Shore NY USA

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