MART 1 variability
Hi Vinnie,
In my experience and in the literature, MART 1
immunoreactivity can vary from melanoma to melanoma and within different
areas of a given melanoma.
Am J Dermatopathol 2000 Jun;22(3):247-50 |
|
The same phenomenon occurs with HMB-45. If your
control nevus was good, there is no reason to doubt the results. In one study,
only 10 of 22 (45%) of malignant melanomas showed MART 1 staining in more than
half of the tumor cells. J Am Acad
Dermatol 2000 Mar;42(3):496-500
Also spindle cell or desmoplastic melanomas are usually MART 1 negative or
only focally positive Am J Surg Pathol 1998 Aug;22(8):976-82
Hope this helps
Jeff Silverman
Southside Hospital
Bay Shore NY USA
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